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Chunk #10 — eQTL analysis of ER-positive breast cancer

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Integrative eQTL-based analyses reveal the biology of breast cancer risk loci.
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Significant associations were determined by applying a false-discovery rate (FDR) threshold of less than 0.1. As a result, from 8,107,200 unique SNP-gene pairs we identified 6,046 associations with raw P-values below 7.50×10-5. These associations mapped to a total of 6,145 SNP loci and 1,359 unique target genes (Table S2, related to Figure 1). The fraction of variation of the expression levels explained by the associated cis-acting SNP loci (R2) ranged from 18.5% to 73.2%.