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Chunk #51 — Discussion — Novelty P3 and Depression

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Novelty P3 reductions in depression: characterization using principal components analysis (PCA) of current source density (CSD) waveforms.
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it would suggest that a motor, rather than an attentional, process is impaired in depression. However, inhibition in the novelty oddball task could extend well beyond the task-specific behavioral response, to encompass autonomic/affective aspects of the orienting response as well. This broadened conceptualization accords well with evidence suggesting a correspondence between frontocentral novelty P3 (but not P3b) and electrodermal evidence of an orienting response as well as the elimination of this association after mild alcohol intoxication (Marinkovic et al., 2001).