In contrast to the strong relationships observed in the foregoing analyses, structural integrity of the DMN as a whole did not vary with verbal (GMV-VM-PLS, p = 0.12) or visuospatial memory capacity (GMV-VSM-PLS, p = 0.41) in patients with mTLE. Given the circumscribed seizure onset in mTLE, we further investigated the structural integrity of the hippocampus itself, using different hippocampal masks including total HC volume, ROIs situated in posterior and anterior HC segments (see Table 2 for MNI coordinates), and the ROI of the HC used in the current PLS analyses, to see if this could be a stronger associate of our memory scores. However, that was not the case (see Fig. S3). The majority of correlations were weak (r2 < 0.1) and non-significant (p > 0.1), with only two regions demonstrating trends toward a relationship with verbal memory capacity (left HC, r2 = 0.05, p = 0.06; left posterior HC r2 = 0.06, p = 0.06).
