In Phase 2 analyses described below, we included publicly available GWAS data (obtained via an application process) from the SAGE dataset, including individuals from the Collaborative Study on the Genetics of Alcoholism (COGA),16 the Family Study of Cocaine Dependence (FSCD),17 and the Collaborative Genetic Study of Nicotine Dependence (COGEND) (http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000092.v1.p1).18 Information on these samples is provided in Supplementary Materials. The combined SAGE analysis set contained 1,311 AA and 2,752 EA individuals (Supplementary Table 1).
