2013. In this revision, issues have again been raised about the term used to define this clinical syndrome. In order to differentiate from the normal physiologic development of tolerance and withdrawal that develops with substance use from the compulsive drug use with loss of control, DSM-5 proposes the use of the word “addiction” to define substance use disorder. The words “dependence“ and “addiction” are used interchangeably in this review to represent the same underlying concept of substance use disorder.
