Long term dysregulation of the HPA axis has been noted in several stress-related psychiatric disorders. Moreover, many studies have shown that childhood trauma can result in HPA axis dysregulation in adulthood and long-lasting increased risk for psychopathology (Enoch, 2011; Mann and Currier, 2010). Numerous studies have reported HPA axis dysfunction in individuals attempting or committing suicide (Arató et al., 1989; Coryell and Schlesser, 2001; Coryell et al., 2006; Jokinen et al., 2007; Jokinen and Nordstrom, 2009; Lindqvist et al., 2008a,b; Mann and Currier, 2007; Nemeroff et al., 1988; Pfennig et al., 2005; Roy, 1992; Roy et al., 1986).
