We evaluated the panel of MANEA SNPs in the EA and AA case-control samples in an attempt to replicate the overall association with cocaine-related traits, to determine whether or not the association is specific to CIP, and to localize the putative biological variant. In the AA replication sample, significant association at the allelic and/or genotypic level was observed between CIP and 5 markers (Table 4). These SNPs and a sixth marker were also associated with CD in the absence of CIP. The strongest and most consistent evidence for association was observed with adjacent markers rs9387522 and rs9387605. In the EA replication sample, the only significant association was found for rs4388292 with CIP, which is accounted for primarily by an underrepresentation of the TT genotype in CIP cases compared with controls. The TT genotype is interestingly also significantly lower in individuals with CD compared with controls in the AA replication sample. Although the results of analyses of individual SNPs did not show an association common to both population groups, haplotype analysis of rs900554 and rs9387522 (ie, 2 of the 3 SNPs
