These results contribute to an emerging field of research examining the association between PGS and brain-based indicators. Previous work in the area of schizophrenia has found null results when attempting to link genetic liability scores and EEG-based indicators (Liu et al., 2017). The results from the current study are somewhat consistent with findings from Harper et al. (2021), which found that genetic liability for substance use behaviors (drinks per week, regular smoking, cannabis use) was significantly associated with EEG-based indicators. However, the principal component defined in part by event-related P3 amplitude was not significantly associated with any substance use behavior PGS’s (Harper et al., 2021).
