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Chunk #20 — RESULTS — Abstinence outcomes

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Influence of a dopamine pathway additive genetic efficacy score on smoking cessation: results from two randomized clinical trials of bupropion.
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AGES scores had similar odds of abstinence in line with the effects of active or placebo treatment received. We explored potential interaction of AGES with gender and FTND. When added as a set, neither of these interaction terms of AGES with FTND (β=0.001; se=0.02, p<0.97) or gender (b=−0.06; se=0.07; p<0.40) were statistically significant in models evaluating lapse risk. Interaction terms evaluating AGES with FTND (β =−0.02; se=0.03, p<0.50) or gender (β =0.04; se= 0.12; p<0.73) also were not significant in the PPA-EOT model.