In this study, we examined the extent to which genetic risk for schizophrenia is associated with 5 self-reported cannabis-related experiences: hallucinations, paranoia, depression and anhedonia, cognitive difficulties, and decreased social contact. We used data from a sample partially ascertained for alcohol use disorders (AUDs)21–23 (74% of the analytic sample met lifetime criteria for AUD, while 70% met lifetime criteria for cannabis use disorder) and tested whether polygenic liability for schizophrenia was associated with cannabis-related experiences in individuals who reported using cannabis at least 11 times during their life.
