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Chunk #13 — Studying Fine-scale Recombination with Increased Sample Size

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Detection of sharing by descent, long-range phasing and haplotype imputation.
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By phasing the parents with LRP, recombination events can be estimated from trio data. In addition to 194 nuclear families with both parents and three or more children genotyped, the 35,528 chip-typed individuals include 1257 and 475 nuclear families with respectively one and two children genotyped. The latter families alone could provide up to 4414 = 2 × (1257 + 2 × 475) meioses for the study of fine-scale recombination.