Chunk #25 — HOW DO NEURAL SIGNATURES ASSOCIATED WITH AUD HELP ELUCIDATE THE ROLE OF BRAIN FUNCTION IN THE RISK AND CONSEQUENCES OF ALCOHOL USE AND AUD ACROSS THE LIFESPAN? — How do genomic factors influence brain functioning across the lifespan and contribute to antecedents and resilience for AUD?
From its inception, COGA has successfully used heritable, reliable, quantitative measures of brain function, to identify key genes that are significantly associated with these neural endophenotypes, advancing our approaches as newer genomic research, technologies and methods emerge (see 2. Sample and Clinical Data). COGA is in a unique position to use its considerable multimodal data to contribute to, as well as move beyond GWAS. COGA's multidisciplinary research team has facilitated translation from genetic variants identified by GWAS to their influence on the developmental trajectories of EEG phenotypes and relationships to substance use and clinical outcomes in longitudinal studies, as well as to perform molecular and functional genetic studies to enhance understanding (see 4. Genetics and 5. Functional Genomics).
