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Chunk #7 — Method — Analysis of Change in Comorbidity

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Decline in genetic influence on the co-occurrence of alcohol, marijuana, and nicotine dependence symptoms from age 14 to 29.
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In addition, because the sample was composed of twins, we used standard twin modeling to decompose the general factor variances into three components: additive genetic (A), shared environment (C), and non-shared environment (E). All analyses were conducted in the same model rather than separate phenotypic and biometric models. Because we set the variance of the general factor to 1, the sum of the A, C, and E variance components of the general factors is also 1. To obtain the average variance in the symptom counts accounted for by genetic influences on the factor, one simply substitutes the term “Var (General Factor)” in the above equation with the corresponding genetic, shared environmental, or non-shared environmental component of the general factor variance. For example, if the age 17 mean squared loading was .4, then that would indicate that 40% of the variance in the symptom counts was due to the general factor. If the additive genetic component A of the age-17 factor was .7, then the genetic influence of the general factor onto the symptom counts would be .4×.7 =.28. That is, 28% of the symptom count variance would be due to the genetic influence of the factor.