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Chunk #20 — Introduction — Rationale for the present study: Mechanisms of Alzheimer’s disease identified as upstream regulators of alcohol-sensitive protein networks in C57BL/6J mice

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Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease.
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Further preclinical research is needed to elucidate the impact of alcohol drinking on MAPT, PSEN-1 and APP to determine if alcohol targets these systems to increase risk of developing neural and behavioral pathologies associated with AD.