A total of 5134 traits are present in GeneNetwork, but they are not all independent because of both the multiple related measures made within studies and the partial overlap of BXD lines used between studies. GeneNetwork developers suggest that Bonferroni correction for 200 independent traits approximates an FDR of 0.2 based on data in (Wang et al., 2016)). We apply a more stringent correction for 2000 independent tests to maintain a conservative significance threshold of 0.05/2000=2.5E-05.
