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Chunk #16 — Disrupted hippocampal–mPFC synchrony in rodent models of schizophrenia

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Oscillations and hippocampal-prefrontal synchrony.
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The prefrontal cortex is one of the main brain regions implicated in the neuropathology of schizophrenia [45]. Moreover, disturbances in functional connectivity between the hippocampus and prefrontal cortex have been reported in schizophrenic patients [46,47]. In light of this, two recent studies have used rodent models of schizophrenia to investigate how oscillatory phase-locking between the hippocampus and mPFC is affected by the disease.