We undertook genome-wide genotyping of 807 411 variants. After filtering, genome-wide imputation using the 1000 Genomes Project Phase 1 and UK10K Project reference panel resulted in 42 795 484 variants. Our final dataset for analysis, after excluding variants with information quality less than 0·5 or minor allele count less than three, comprised 28 509 962 imputed or genotyped variants in 48 931 unrelated individuals (table 1 and appendix pp 16 and 95).23
