(for meta-analysis see Talmud et al., 2011) and substance abuse (Clarke et al., 2012; Merenakk et al., 2011; Prestes et al., 2007). Given the neurobiological implications, this gene should be considered a strong candidate in future alcohol abuse studies. The final three genome-wide suggestive (q<0.2) loci were for intronic SNPs in ZNF578, MIPOL1 and IGSF9B and have no reported evidence linking them to alcohol use/abuse phenotypes. Thus, future research will be required to adjudicate whether they are novel susceptibility loci or false discoveries.
