paperKB
coga / coga-kb
Help
Sign in

Chunk #12 — RESULTS — Reduced AcbC Crem expression mediates impulsive action

Source
Ventral striatal regulation of CREM mediates impulsive action and drug addiction vulnerability.
Embedded
yes

Text

with impulsive action, not impulsive choice, compulsivity or general hyperactivity. For heroin SA, HSV-Crem-Gfp or HSV-Gfp was bilaterally infused into the AcbC of a different cohort of animals the day before the first session. Over-expression did not impact responses on the heroin-associated active lever but significantly decreased inactive lever pressing (F1,9=13.50, p=0.005, Fig. 2f). These data indicate that AcbC Crem does not affect heroin reinforcement per se but decreases impulsive action in the context of a reward-related behavior.