In conclusion, several variables had significant effects on AOO of AUD in this study: sex, family history, age of first drink, peer drinking, comorbidity, and PRS. Discriminatory power in the ROC model was maximized by using age of first drink along with other variables. PRS was useful in identifying subgroups at unusually high risk. Such algorithms might have a place in the future clinical practice of psychiatry. Larger samples, especially AA samples, will be necessary to support more effective use of PRS in diverse clinical populations. In combination with clinical variables, PRS may aid in prediction of outcome and clinical decision making. Following additional study, clinical trials may help to assess feasibility and utility.
