A major challenge for GTEx was in the management of data associated with the biospecimens; each case could include more than 500 data elements. To help manage the data, a system for data queries was implemented and this process proved to be an effective method for producing well-organized, easily accessible, and reliable data. Implementation of data management techniques can be time consuming and burdensome. However, such techniques provided real time feedback to the BSSs on their protocol conduct, which resulted in site improvements and improved adherence to protocol.