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Chunk #10 — Social and Cultural Factors Modulate Alcohol Drinking by ALDH2 Heterozygotes

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The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption.
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There are many East Asians now living in Western societies, particularly at universities and in metropolitan areas. A sub-population of special concern is ALDH2-deficient university students who may face peer pressure for heavy drinking and binge drinking. Furthermore, anecdotal evidence indicates that some young people view the facial flushing response as a cosmetic problem and use antihistamines in an effort to blunt the flushing while continuing to drink alcohol [28]. This practice is expected to increase the likelihood of developing esophageal cancer.