Chunk #15 — Indirect modulation of inhibitory synaptic transmission by ACh

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Cholinergic modulation of synaptic integration and dendritic excitability in the striatum.

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In addition to its direct modulation on voltage-gated and ligand-gated channels, ACh also exerts its modulatory effect through the endocannabinoid (eCB) system, which may influence synaptic transmission and synaptic plasticity in the striatum (figure2).