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Chunk #16 — 4. Selectively bred high alcohol-consuming rat lines and their phenotypic characteristics

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Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity.
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describe the five oldest selectively bred high vs. low alcohol-consuming rat lines in the world. The text gives a brief overview of neurobehavioral and neurochemical differences found between the respective lines. The brief overview focuses primarily on observations associated with criteria for an animal model of alcoholism and some neurobehavioral and neuro-chemical correlates associated with alcoholism. Table 3 gives more in-depth information on direct comparisons within the line-pairs and parameters associated with observed neurobiological differences (e.g., brain regions).