of the subset of common trans-QTLs, 64 are in Qrr1 (figure 1). The replication rate of trans-QTLs in Qrr1 is therefore about 6-fold higher relative to the rest of the genome. When we compared the BXD hippocampus dataset with the B6C3HF2 brain dataset (assayed on Agilent arrays), we found 54 trans-QTLs common to both datasets (for the common trans-QTLs, the average distance between peak markers in the two datasets is 2.7 Mb). Strikingly, out of the 54 trans-QTLs common to both crosses, 52 are in Qrr1 (figure 1).
