We then looked at the characteristics of the 1111 SCZ genes (and the high-confidence subset of 321). As expected, they shared many characteristics with known SCZ-associated genes, being enriched in translational regulators, cholinergic receptors, calcium channels, synaptic genes, SCZ differentially expressed genes, and loss-of-function-intolerant genes (fig. S45) (47). Next, we identified the TFs regulating the SCZ genes (on the basis of our regulatory network, either directly or via an enhancer) (Fig. 6D). These include LHX9 and SOX7, TFs critical for early cortical specification and neuronal apoptosis, respectively (48, 49). Lastly, we integrated the SCZ genes with single-cell profiles and found that they are highly expressed in neurons, particularly excitatory ones, consistent with the recent findings (Fig. 6E) (47).
