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Chunk #22 — Discussion

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Polygenic risk for externalizing disorders: Gene-by-development and gene-by-environment effects in adolescents and young adults.
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adolescents and young adults. This nicely maps onto evidence from twin studies that a highly heritable behavioral disinhibition factor broadly predisposes individuals to a range of externalizing disorders (Kendler et al., 2003; Krueger et al., 2002). The differential age associations for conscientiousness and sensation seeking (whereby polygenic scores predicted lower levels of adolescent conscientiousness (i.e., constraint) and higher levels of young adult sensation seeking, but not the reverse) suggest that the genetic influences on distinct impulsivity dimensions may change across development.