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Chunk #17 — RESULTS — Neuroimaging Results — Effect of Task in 2-back Working Memory

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Resiliency in adolescents at high risk for substance abuse: flexible adaptation via subthalamic nucleus and linkage to drinking and drug use in early adulthood.
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Second level analysis for the entire sample (n=67) revealed working memory task activation occurred in right prefrontal and anterior cingulate cortex, inferior parietal lobe and left inferior frontal gyrus similar to previous studies (Callicott et al., 1999, Braver et al., 1997, Jansma et al., 2000, Owen et al., 2005). Task-related reductions in activation were found in posterior cingulate cortex, medial frontal regions and bilateral pre-/post-central gyri similar to previous work (Hampson et al., 2006). See Figure 2 for 2-back versus 0-back contrast mappings and supplemental Table S2.