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Chunk #41 — ONLINE METHODS — Data acquisition, quality control, and normalization — Association of intron usage with Alzheimer’s disease and neuropathology traits.

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Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility.
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We used variancePartition59 to estimate the proportion of variance explained of differently excised introns association with Alzheimer’s disease, burden of amyloid, burden of tangles, and neuritic plaques.