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Chunk #20 — Materials and Methods — Data Analyses

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Prefrontal response and frontostriatal functional connectivity to monetary reward in abstinent alcohol-dependent young adults.
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a covariate in these regression analyses. All analyses initially used a voxel-wise threshold of p<.05 and a minimum extent of 10 contiguous voxels. We then used simulations in AlphaSim based on the five-ROI mask to compute minimum cluster sizes in order to adjust for Type I error in all analyses. The minimum extent size of continuous voxels required for a corrected p<.05 cutoff using the entire mask was 247 voxels.