Attempts to replicate this association using Asian samples have been mixed. Significant associations of rs1344706 with SZ risk were observed in Han Chinese and Indonesian samples (Schwab et al., 2013; Zhang et al., 2011b; Zhang et al., 2012). However, GWAS replication studies (Li et al., 2011; Yue et al., 2011) and recent meta-analyses (Li et al., 2012; Li et al., 2013) have shown that rs1344706 is not a risk SNP for SZ in the Chinese population, suggesting potential genetic heterogeneity of SZ susceptibility at this locus. Moreover, the rs4380187 SNP near ZNF804A almost met genome-wide significance (p = 5.66 × 10–8) in a recently published large-scale collaborative GWAS (Ripke et al., 2013).
