Within the CeA, Pape and co-workers showed that 24 hours after a single tone-foot shock pairing, the magnitude of DSI and DSE was enhanced in neurons from the CeAM (Kamprath et al., 2011). This effect was not observed 3 days after foot-shock stress. These findings suggest that strong acute stressors can cause transient enhancements in short-term eCB signaling in the CeAM (Kamprath et al., 2011). The biochemical mechanisms subserving these adaptations require further investigation.
