In addition to the eight genomewide-significant signals, a highly suggestive signal of unusual differentiation was observed at the SNP rs13107325 (nominal P-value = 2×10−7, P-value = 0.06 after correcting for 284,191 common SNPs tested) (Table 3). This SNP is a missense coding SNP inside the SLC39A8 (solute carrier family 39 (zinc transporter), member 8) gene (http://genome.ucsc.edu/), and allele frequencies in HapMap [27] indicate that the minor allele of this SNP is private to populations of European ancestry (Table S1). Thus, although this SNP did not meet our strict criteria for genome-wide significance, it is an intriguing candidate for natural selection.
