Locomotor response to MDMA. On Day 1, all mice were weighed, injected with saline (10 ml/kg, s.c.) and placed in the Open Field Chamber (MED-OFA-510, Med Associates). Activity was recorded for 90 min. On Day 2, mice were habituated to the Open Field chamber for 60 min. They were then injected with saline (10 ml/kg, s.c.) or MDMA (10 mg/kg, s.c.). Activity was recorded for 90 min.