As investigators who have explored cGxE hypotheses ourselves, with some of our own work not meeting the standards delineated in this review, we were compelled to ask: how can we do better? We hope we have outlined some such strategies. Through greater awareness of the challenges in conducting cGxE research, resources available to aid in conducting high quality cGxE studies, and proactive efforts to move cGxE studies in this direction, it is our hope that this growing area of research will eventually reach its potential to deeply inform to our understanding of complex behavioral outcomes.
