Results of the follow-up analysis for all SNPs with P-value < 1 × 10−5 in the Generation Scotland cohort are displayed in eTable 4. Rs35855737 is not significantly associated with neuroticism in the Generation Scotland cohort, but the direction of the effect is the same (beta=−0.02 for effect allele C; P-value=0.32). A meta-analysis of the results from all 30 cohorts shows that rs35855737 remains genome-wide significant (beta=−0.04; P-value=2.38 × 10−8).