mRNA targets included in the Target Scan database: ISL1, ACVR2B and PSKH1. ISL1 is a transcription factor of the LIM/homeodomain family, involved in regulating expression of the insulin gene in islet cells [49] and previously noted to be differentially expressed between visceral and subcutaneous fat and negatively correlated with BMI [50]. Taken together, our results, supported by recent publications, reflect an important role of miRNAs in contributing to the general molecular phenotypic profile in each one of these two adipose tissues.
