In order to determine whether these changes were specific to drug abuse or might reflect a common physiological response to cardiovascular disease, as common complication in drug abuse cases, or oxidative stress secondary to drug abuse, we examined control cases with or without cardiovascular disease. Six overweight-obese control cases with cardiovascular disease and six normal-overweight control cases with no history of cardiovascular disease were compared. GAP scores did not reach significance for any of transcripts identified to be increased or deceased in drug abuse cases ( Table 3 , Table S2 ).
