We performed a GWAS of 20 samples in total: 18 from the Psychiatric Genomics Consortium Substance Use Disorders working group (European ancestry 8277 cases, 23 497 controls; African ancestry 3848 cases, 5897 controls), one iPSYCH9 sample (European ancestry 2758 cases, 53 326 controls), and one deCODE sample (European ancestry 6033 cases, 280 396 controls; table 1; appendix pp 2–8).Table 1Numbers of cases and controls in meta-analysisEuropean ancestryAfrican ancestryEuropean ancestry—case-control individualsCasesControlsCasesControlsCasesControlsCase-control studiesCATS958453....958453CADD3976995955397699CHDS201420....201420FSCD226314199401226314COGEND Nico306607154313306607COGEND SAGE22883079187228830GEDI-GSMS81491....81491ADAA....1000811....Total239738141491176723973814Family-based studiesBLTS1701216....147662MCTFR4491625....3891185Yale Penn 191683311891857839657Yale Penn 2557497355548557495bigCOGA220650538131725248795CEDAR64148....64148OZ-ALC5934893....4701534VTSABD99734....94361IASPSAD104613....84353Total515815 6122357413028926190Summary statisticsAdd health7224071........PGC studies total82772349738485897528910 004iPSYCH27585332600275853 326deCODE6033280 396006033280 396Total (European ancestry)17 068357 219....14 080343 726Total (Transancestral)20 916 cases;36 3116 controls..........ADAA=Alcohol Dependence in African Americans. BLTS= Brisbane Longitudinal Twin Study. CADD=Center on Antisocial Drug Dependence. CATS=Comorbidity and Trauma Study. CEDAR= Center for Education and Drug Abuse Research. CHDS=Christchurch Health and Development Study. COGA=Collaborative Study on the Genetics of Alcoholism. COGEND=Collaborative Genetic Study of Nicotine Dependence. FSCD=Family Study of Cocaine Dependence. GEDI=Gene-Environment-Development Initiative. GSMS=Great Smoky Mountains Study. IASPSAD=Irish Affected Sib-Pair Study of Alcohol Dependence. MCTFR= Minnesota Center for Twin and Family Research. OZ-ALC=Australian Alcohol and Nicotine Studies. SAGE=Study of Addiction: Genetics and Environment. VTSABD=Virginia Twin Studies of Adolescent Behavioral Development.
