Many investigators would conduct regional “deep” re-sequencing of large numbers of cases and controls to discover previously unknown genetic variants. The emerging technology of genome resequencing has shown that there are usually an array of undiscovered genetic variants. A more detailed understanding of genetic variation in human populations will soon be available through the 1000 Genomes Project (http://www.1000genomes.org) which is performing genomic resequencing of > 1000 people from around the world. This is likely to prove very informative in guiding fine-mapping studies and potentially untangling more complex effects on phenotype.
