et al., 2004) were selected to improve coverage of the CHRN genes. Third, because of the strong associations with case-control status in the CHRNA5/CHRNA3/CHRNB4 and CHRNB3/CHRNA6 gene clusters, we densely covered these regions for fine-mapping. All SNPs were required to have call rates ≥ 98%, leading to a final analysis set of 226 SNPs (118 newly genotyped by CIDR). Map positions were obtained from the UCSC Genome Browser (genome.ucsc.edu) Human March 2006 Assembly.