several psychiatric disorders for which Neuroticism is an intermediate phenotype/endophenotype. In the follow-up samples we found a trend, in the same direction, for the association of SNAP25 with Neuroticism (P = .097). A SNP in the gene TMEM16D (rs1849710; P = 2.29 × 10−5), maps in the 12q region relatively close to the marker D12S346, which showed the strongest linkage peak in a extremely discordant and concordant sibling pairs study, particularly among female pairs (4). To examine sex-specific effects in the Sardinian sample, we conducted additional association analyses in women and men separately (sex-specific P-values for the SNPs in Table 1 are presented in supplementary Table B). Results indicate that rs1849710 on 12q was associated with Neuroticism in females (P = 4.34 × 10−4) and also males (P = 4.39 × 10−3). No sex-specific effects reached genome-wide significance using the stringent Bonferroni correction.
