The ability to generate neurons from participant fibroblasts has made it possible to examine and study living neurons from individual subjects with different diseases (Chamberlain et al., 2008). Current research has focused on the use of iPS cell technologies to examine mechanisms of neurodegenerative disease such as amyotrophic lateral sclerosis, spinal muscular atrophy, and Parkinson’s disease (Yamanaka, 2009), and genetic, neurodevelopmental diseases including Angelman syndrome and Prader-Willi syndrome (Chamberlain et al., 2010). To our knowledge, there are no reports of research using human iPS-derived neural cells as a model for the molecular actions of alcohol and the development of alcohol use disorders.
