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Chunk #16 — HERITABILITY IN BRAIN DEVELOPMENT: FAMILY AND TWIN STUDIES — Brain morphometry studies on heritability

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Genetic influences on brain developmental trajectories on neuroimaging studies: from infancy to young adulthood.
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Yang et al. 2012). As in adults (Tramo et al. 1998; Joshi et al. 2011), differences in heritability were observed between hemispheres in adolescents in multiple frontal regions (Schmitt et al., 2009; Yang et al. 2012). In 9 and 12 years old children, heritability of cortical thinning was predominantly found in superior and middle frontal regions, superior temporal cortices, cingulate, sensorimotor cortices, and primary visual and lateral occipital cortices (van Soelen et al. 2012b). Inferior regions of the primary motor and sensory cortex in the frontal and postgyral cortices that are associated with facial recognition functions showed a higher heritability in early development compared to other brain regions, and an increasing heritability with age (Lenroot et al. 2009; van Soelen et al. 2013). From later childhood through adolescence, heritability increased most markedly in dorsolateral prefrontal, superior parietal and temporal cortices, and in language-related regions in the left hemisphere including Broca and Wernicke’s areas (Lenroot et al. 2009; van Soelen et al. 2013).