same set of analyses in an independent cohort of Australian twins (QIMR Twins) [15], [16]. We subsequently generate these allelic scores which index BMI, CRP and LDLc in publicly available data from the first Wellcome Trust Case Control Consortium [17], and investigate the extent to which the scores are associated with case control status across seven common diseases (Bipolar disorder, Coronary Artery Disease, Crohn's Disease, Hypertension, Rheumatoid Arthritis, Type I Diabetes, Type II Diabetes).