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Chunk #7 — The Theoretical Basis for the Present Study

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Polygenic Score × Intervention Moderation: an Application of Discrete-Time Survival Analysis to Model the Timing of First Marijuana Use Among Urban Youth.
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age of first cigarette smoked was via its effect on delaying the reported age a cigarette was first offered by a peer. Synthesizing these 4 lines of evidence, we contended that the quit success score may be an index of one’s sensitivity to the reinforcing effects of substances and that that frequent and prolonged exposure to cigarette smoke within one’s peer group may increase the likelihood of inhaling secondary smoke and experiencing the reinforcing effects of a variety of substances. This, in turn, would then make it more likely that the non-smoker would accept an offer to try any substance from his/her friends. Finally, the effect of early elementary school interventions on age of first use might vary as a function of one’s sensitivity to reinforcing effects of nicotine within the context of interactions with friends who smoke cigarettes.