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Chunk #11 — 1. Introduction — 1.2. Neurophysiologic abnormalities in the psychosis prodrome

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Olfaction in the psychosis prodrome: electrophysiological and behavioral measures of odor detection.
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smell identification deficit as a candidate endophenotype for schizophrenia (Brewer et al., 2003). Using an odor detection task with two concentrations of H2S, we replicated and extended olfactory ERP findings for schizophrenia patients (Kayser et al., 2010). The patients (n = 32) showed regional amplitude reductions of N1 over inferior frontotemporal sites and of P2 over medial parietal sites, despite patients having similar odor detection performance as healthy controls (n = 35).