Chunk #51 — Online Methods — Expression data preprocessing — Cross-platform replications

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Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression.

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To test the performance of the empirical probe-matching approach, we conducted discovery cis-, trans- and eQTS meta-analyses for each expression platform (RNA-seq, Illumina, Affymetrix U219 and Affymetrix Hu-Ex v1.0 ST arrays; array probes matched to 19,942 genes by empirical probe matching). For each discovery analysis, we conducted replication analyses in the three remaining platforms.