Chunk #20 — METHODS — Advantages of multivariable MR‐Egger and comparison with univariable MR‐Egger

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Extending the MR-Egger method for multivariable Mendelian randomization to correct for both measured and unmeasured pleiotropy.

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The bias for the causal estimate from univariable MR‐Egger θ^UE depends on the weighted covariance between α and βX1, where (13)αj=αj′+∑i=2KθiβXij.