By contrast, the HDAC9 and 9p21 associations were specific to large-vessel stroke, and not present with other stroke subtypes. An association with the 9p21 locus was first associated with myocardial infarction and coronary artery disease but has now been associated more widely with other arterial diseases such as aneurysms and ischaemic stroke.10, 24 HDAC9 was recently identified in the WTCCC2 ischaemic stroke study as a novel association with ischaemic stroke,14 having not previously been shown in GWAS analyses of ischaemic heart disease.
